Developmental/reproductive toxicity |
Type of Concern |
Reference |
Known human reproductive toxicant | European Union - Classification & Labelling |
Possible human developmental toxicant | California EPA Proposition 65 |
Human reproductive toxicant - strong evidence | CHE Toxicant and Disease Database |
Human nervous system toxicant - strong evidence | CHE Toxicant and Disease Database |
Human reproductive toxicant - strong evidence | |
Human developmental toxicant - strong evidence | |
Human developmental toxicant - moderate evidence | CHE Toxicant and Disease Database |
Human nervous system toxicant - moderate evidence | Chemicals known to be neurotoxic to humans |
Human reproductive toxicant - moderate evidence | CHE Toxicant and Disease Database |
Limited evidence of reproductive toxicity | National Library of Medicine HazMap |
Limited evidence of developmental toxicity | European Union - Classification & Labelling |
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Limited evidence of musculoskeletal toxicity | CHE Toxicant and Disease Database |
Limited evidence of developmental toxicity | CHE Toxicant and Disease Database | |
Cancer |
Type of Concern |
Reference |
Possible human carcinogen | EPA Integrated Risk Information System (IRIS) |
Possible human carcinogen | Int'l Agency for Research on Cancer (IARC) - Carcinogens |
Possible human carcinogen | NTP Report on Carcinogens, 11th Edition |
Possible human carcinogen | California EPA Proposition 65 |
Cancer - strong evidence | |
Limited evidence of carcinogenicity | Amer Conf of Gov't Industrial Hygienists - Carcinogens |
Limited evidence of carcinogenicity | Int'l Agency for Research on Cancer (IARC) - Carcinogens |
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Cancer - limited evidence | CHE Toxicant and Disease Database |
Cancer - not classifiable/not likely to be human carcinogen | Int'l Agency for Research on Cancer (IARC) - Carcinogens | |
Organ system toxicity (non-reproductive) |
Type of Concern |
Reference |
Known human respiratory toxicant | EPA Hazardous Air Pollutants |
Known human renal toxicant | CHE Toxicant and Disease Database |
Known human hematologic toxicant | CHE Toxicant and Disease Database |
Known human sense organ toxicant | CHE Toxicant and Disease Database |
Known human cardiovascular toxicant | CHE Toxicant and Disease Database |
Known human musculoskeletal toxicant | CHE Toxicant and Disease Database |
Possible human cardiovascular toxicant | CHE Toxicant and Disease Database |
Possible human renal toxicant | CHE Toxicant and Disease Database |
Possible human hematologic toxicant | CHE Toxicant and Disease Database |
Classified as expected to be toxic or harmful | Environment Canada Domestic Substance List |
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Classified as toxic or harmful | European Union - Classification & Labelling |
One or more animal studies show classified as toxic effects at low doses | EPA Categorized List of Inert Pesticide Ingredients |
Limited evidence of musculoskeletal toxicity | CHE Toxicant and Disease Database |
Limited evidence of renal toxicity | CHE Toxicant and Disease Database |
Limited evidence of cardiovascular or blood toxicity | National Library of Medicine HazMap |
Limited evidence of cardiovascular or blood toxicity | |
Limited evidence of kidney toxicity | |
Limited evidence of gastrointestinal or liver toxicity | |
Limited evidence of sense organ toxicity | |
Limited evidence of respiratory toxicity | |
reproductive - weight of evidence unknown/unassessed/unreview: published lit review or major tox study | National Library of Medicine HazMap |
Classified as a low human health priority | Environment Canada Domestic Substance List | |
Persistence and bioaccumulation |
Type of Concern |
Reference |
Persistent, bioaccumulative in wildlife and humans | EPA Toxic Release Inventory PBTs |
Persistent or bioaccumulative and moderate to high toxicity concern in humans | Environment Canada Domestic Substance List |
Persistent, bioaccumulative in wildlife | Canada PBTs - Accelerated Reduction/Elimination of Toxics (ARET) |
Persistent, bioaccumulative in wildlife | Great Lakes BTS (Binational Toxics Strategy) PBTs |
Persistent, bioaccumulative in wildlife | EPA PBTs - Waste Minimization Program (RCRA) |
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Not suspected to be bioaccumulative | Environment Canada Domestic Substance List | |
references |
government/industry list/academic study
| reference
|
European Union - Classification & Labelling | CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP. |
Amer Conf of Gov't Industrial Hygienists - Carcinogens | ACGIH (American Conference of Governmental Industrial Hygienists) 2008. ACGIH cancer classification system. www.acgih.org. |
Canada - Prohibited and Restricted Cosmetics Ingredients | Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007. |
CHE Toxicant and Disease Database | CHE (The Collaborative on Health and the Environment). 2006. Toxicant and Disease Database. |
EPA Clean Water Act - Priority Pollutants | |
Environment Canada Domestic Substance List | EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. |
Illinois EPA Chemicals Associated with Endocrine System | Illinois EPA (Illinois Environmental Protection Agency). 2000. Preliminary list of chemicals associated with endocrine system effects in animals and humans (*) or in vitro (+). In EPA (U.S. Environmental Protection Agency) 2000. Handbook for Non-Cancer Health Effects Valuation, Appendix C. |
EPA Integrated Risk Information System (IRIS) | EPA (U.S. Environmental Protection Agency). 2008. Integrated Risk Information System (IRIS). Evidence for human carcinogenicity based on 1986-2005 guidelines. |
European Commission on Endocrine Disruption | EU (European Union)- Strategy for Endocrine Disrupters 2007. Commision on endocrin disruption requested by the European Parliament in 1998. |
European Union - Banned or Restricted in Cosmetics | EC (European Commission of the European Union). 1999-2006. Enterprise Directorate-General Pharmaceuticals and Cosmetics. The rules governing cosmetic products in the European Union, Volume 1, "Cosmetics legislation." |
European Union - Water Framework Directive | EU (European Union). 2000. Water Framework Directive (Directive 2000/60/EC ) - integrated river basin management for Europe. List of priority substances. |
EPA Hazardous Air Pollutants | EPA (U.S. Environmental Protection Agency). 2005. Office of Air. The 112(b)1 Hazardous Air Pollutants List (as modified). Last modified: 12 Dec 2005. |
National Library of Medicine HazMap | NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents. |
Int'l Agency for Research on Cancer (IARC) - Carcinogens | IARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99 (a total of 935 agents, mixtures and exposures). |
EPA Categorized List of Inert Pesticide Ingredients | EPA (U.S. Environmental Protection Agency). 1987 & 2005. Office of Pesticide Programs. Inert (other) Pesticide Ingredients in Pesticide Products - Categorized List of Inert (other) Pesticide Ingredients. |
Nanomaterial Database | NanoWerk. 2007. Nanomaterial Database. Available online: http://www.nanowerk.com/phpscripts/n_dbsearch.php |
Chemicals known to be neurotoxic to humans | Grandjean P and PJ Landrigan. 2006. Developmental neurotoxicity of industrial chemicals. Lancet. 2006 Dec 16;368(9553):2167-78. |
NTP Report on Carcinogens, 11th Edition | NTP (National Toxicology Program). 2005. Report on Carcinogens, Eleventh Edition; U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program. |
Our Stolen Future Endocrine Disruptors | Colborn T, D Dumanoski, JP Myers. 2006. Widespread Pollutants with Endocrine-disrupting Effects. Updated from original listing in "Our Stolen Future" (1996). |
Canada PBTs - Accelerated Reduction/Elimination of Toxics (ARET) | EC (Environment Canada). 1994. Accelerated Reduction/Elimination of Toxics (ARET). ARET substance list of persistent, bioaccumulative and toxic chemicals. |
Great Lakes BTS (Binational Toxics Strategy) PBTs | Great Lakes BTS (Binational Toxics Strategy). 1997. Canada-United States Strategy for the Virtual Elimination of Persistent Toxic Substances in the Great Lakes. Appendix I - Level 1 and Level 2 substances. |
EPA PBTs - Waste Minimization Program (RCRA) | EPA (U.S. Environmental Protection Agency). 1998. Resource Conservatin and Recovery Act (RCRA) Waste Minimization Program - priority chemicals for elimination or reduction. |
EPA Toxic Release Inventory PBTs | EPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule. |
California EPA Proposition 65 | California EPA (California Environmental Protection Agency). 9/2008. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity. |
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