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Synonym(s): M-DIMETHYLBENZENE; 1,3-DIMETHYLBENZENE; BENZENE, 1,3-DIMETHYL- (9CI) ; M-METHYLTOLUENE; 1,3-XYLENE; M-XYLENE (ACGIH:OSHA) ; M-XYLOL
Neurotoxicity | ||
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Type of Concern | Reference | |
Strong evidence of human neurotoxicity | Chemicals known to be neurotoxic to humans | |
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Organ system toxicity (non-reproductive) | ||
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Type of Concern | Reference | |
Known human respiratory toxicant | EPA Hazardous Air Pollutants | |
Possible human cardiovascular toxicant | CHE Toxicant and Disease Database | |
Possible human sense organ toxicant | CHE Toxicant and Disease Database | |
Possible human musculoskeletal toxicant | CHE Toxicant and Disease Database | |
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Developmental/reproductive toxicity | ||
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Type of Concern | Reference | |
Limited evidence of reproductive toxicity | National Library of Medicine HazMap | |
Human nervous system toxicant - moderate evidence | CHE Toxicant and Disease Database | |
Human developmental toxicant - moderate evidence | CHE Toxicant and Disease Database | |
Human reproductive toxicant - moderate evidence | CHE Toxicant and Disease Database | |
Human nervous system toxicant - moderate evidence | Chemicals known to be neurotoxic to humans | |
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Allergies/immunotoxicity | ||
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Type of Concern | Reference | |
Limited evidence of immune system toxicity |
Cancer | ||
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Type of Concern | Reference | |
Cancer - limited evidence | CHE Toxicant and Disease Database |
Occupational hazards | ||
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Type of Concern | Reference | |
Allowed workplace exposures restricted to low doses | European Union - Classification & Labelling |
Irritation (skin, eyes, or lungs) | ||
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Type of Concern | Reference | |
Classified as irritant | European Union - Classification & Labelling |
Persistence and bioaccumulation | ||
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Type of Concern | Reference | |
Not suspected to be persistent | Environment Canada Domestic Substance List | |
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Miscellaneous | ||
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Type of Concern | Reference | |
Occupational hazards related to handling | European Union - Classification & Labelling |
Ecotoxicology | ||
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Type of Concern | Reference | |
Not suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Data gaps | ||
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Type of Concern | Reference | |
Not assessed for safety in cosmetics by industry panel |
Government, industry, academic studies and classifications |
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government/industry list/academic study | appears on list as | classification(s) |
references |
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government/industry list/academic study | reference | |
European Union - Classification & Labelling | CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP. | |
CHE Toxicant and Disease Database | CHE (The Collaborative on Health and the Environment). 2006. Toxicant and Disease Database. | |
Environment Canada Domestic Substance List | EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. | |
EPA Hazardous Air Pollutants | EPA (U.S. Environmental Protection Agency). 2005. Office of Air. The 112(b)1 Hazardous Air Pollutants List (as modified). Last modified: 12 Dec 2005. | |
National Library of Medicine HazMap | NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents. | |
EPA Categorized List of Inert Pesticide Ingredients | EPA (U.S. Environmental Protection Agency). 1987 & 2005. Office of Pesticide Programs. Inert (other) Pesticide Ingredients in Pesticide Products - Categorized List of Inert (other) Pesticide Ingredients. | |
Chemicals known to be neurotoxic to humans | Grandjean P and PJ Landrigan. 2006. Developmental neurotoxicity of industrial chemicals. Lancet. 2006 Dec 16;368(9553):2167-78. | |
EPA Toxic Release Inventory PBTs | EPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule. |
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